Author's details
- Dr. Khashau Eleburuike
- MBBS (Ilorin) MSc. Global Health Karolinska Institute.
- Resident doctor in family medicine in Northern Sweden.
Reviewer's details
- Abdurrazzaq Alege
- MBBS, MBA (Healthcare Mgt), FMCPaed, FIPNA.
- Consultant Paediatrician/Paediatric Nephrologist, Federal Teaching Hospital, Katsina, Nigeria.

- Date Published: 2025-04-28
- Date Updated: 2025-04-28
Patient Information: Understanding Nephrotic Syndrome in Children
✅ What is Nephrotic Syndrome?
Nephrotic Syndrome is a kidney condition where the kidneys leak too much protein into the urine. This leads to:
- Body Swelling (especially in the face, legs, or belly)
- Foamy urine
- Weight gain from fluid
- Low protein levels in the blood
The kidneys normally act like a filter, keeping important things like protein in the blood. In nephrotic syndrome, that filter becomes “leaky.”
🧒 Who Gets It?
Nephrotic syndrome:
- Is common in children between 2 and 6 years old
- Can affect both boys and girls (but slightly more common in boys)
- May occur after a viral illness
- Is not contagious, and not caused by curses or witchcraft
📋 What Are the Symptoms?
Watch for:
- Swelling around the eyes (especially in the morning)
- Swollen feet, ankles, or belly
- Foamy or bubbly urine
- Reduced urine (less frequent urination)
- Weight gain (due to fluid, not fat)
- Tiredness or poor appetite
If untreated, it can lead to infections, blood clots, or kidney failure.
🔍 What Causes It?
In most children, the cause is Minimal Change Disease (MCD), which means the kidneys look normal under a microscope but still leak protein. The exact cause is often unknown, but it is not the parents’ fault.
In other cases, nephrotic syndrome can be caused by:
- Infections like malaria, hepatitis B, or HIV
- Certain medicines and creams especially bleaching creams
- Autoimmune diseases
- It may follow some animal bites e.g bee stings, insect bites
🏥 How is It Diagnosed?
At a health facility, your child may have:
- Urine test (shows large amounts of protein)
- Blood test (low protein, high cholesterol)
- Kidney function test
- Sometimes, a kidney biopsy (small tissue sample for testing)
💊 How is It Treated?
- Steroid Medicine (Prednisolone):
Most children respond well to steroids within a few weeks. Treatment usually lasts for several months. - Salt and Water Control:
- Reduce salt in food to manage swelling
- Monitor fluid intake, especially when swelling is severe
- Infection Prevention:
- Children are more prone to infections. Treat infections promptly.
- Keep immunizations up to date
- Avoid crowded places when immunity is low
- See a health worker early if your child has fever, cough, or stomach pain
- Other Medicines:
If steroids don’t work or there are frequent relapses, the doctor may add other medications to help protect the kidneys.
🔁 Can It Come Back?
Yes. Nephrotic syndrome often goes away and comes back (relapses). Common triggers for relapse include:
- Infections (like colds)
- Stopping medicines too soon
- Stress or fatigue
Most children eventually outgrow the condition as they get older, especially if well managed.
🚨 When to Seek Help Immediately
Go to a health center or hospital if your child:
- Has trouble breathing
- Becomes very swollen or weak
- Passes very little or no urine
- Has fever, belly pain, or blood in the urine
- Has signs of a relapse (swelling, foamy urine)
❤️ Caring for a Child with Nephrotic Syndrome
- Give all medicines exactly as prescribed
- Take your child for regular follow-up visits
- Keep a record of urine test (for protein and blood). This can be done at home
- Keep a record of weight, urine output, and swelling
- Offer emotional support – relapses are common but manageable
- Avoid herbal or unverified treatments unless approved by a doctor
🧠 Important Reminders
Myth | Truth |
---|---|
It's caused by evil spirits or curses | It's a medical condition involving the kidneys |
All swelling in children is malnutrition | Swelling can also be from kidney disease |
Once treated, it never returns | Nephrotic syndrome can relapse, but it is manageable |
It is a permanent kidney disease | It is treatable and many children often outgrow it |
🏁 Final Word
Nephrotic syndrome is a serious but treatable condition. With proper care, most children recover well and can lead normal lives. Work closely with health workers and keep track of your child’s health at home.
- Eddy AA, Symons JM. (2003). Nephrotic Syndrome in Childhood. The Lancet, 362(9384), 629–639.
- KDIGO Clinical Practice Guidelines (2021). Glomerular Diseases Guideline – Nephrotic Syndrome in Children. https://kdigo.org
- International Pediatric Nephrology Association (IPNA). (2022). Management of Pediatric Nephrotic Syndrome in Low-Resource Settings.
- World Health Organization (WHO). (2020). Improving Care for Children with Chronic Kidney Disease.
- National Kidney Foundation. (2021). Nephrotic Syndrome Information Sheet. https://www.kidney.org
